![]() ![]() We have previously reported that chronic supplementation of taurine in drinking water to mice increases brain excitability, mainly through alterations in the inhibitory GABAergic system. Prof Ilaria Bellantuono: My research is funded by the Dunhill Medical Trust and the Michael J Fox Foundation.Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. ![]() was published in Science at 18:00 UK time Thursday 8 June 2023. ‘ Taurine deficiency as a driver of aging’ by Parminder Singh et al. However, it needs to be carefully tested in all these conditions before being able to draw any conclusion.” If there is a demonstrable clinical impact it could be used to prevent multiple long-term chronic conditions such as osteoporosis, muscle weakness, diabetes and potentially neurodegenerative diseases. What are the implications in the real world? Is there any overspeculation? It is a very early study and there is some way to go before we can say if it is relevant to humans.” ![]() Have the authors accounted for confounders?Īre there important limitations to be aware of? The major issue we face is how do we translate to benefit people, who should take it, for how long, is it safe and how to make it cost-effective?” The mechanisms modulated by taurine are the main mechanisms driving ageing and we have seen several molecules interfering with similar mechanisms having the same effects. I think it fits well with the existing evidence. How does this work fit with the existing evidence? Is this good quality research? Are the conclusions backed up by solid data? It was tested in naturally ageing animals.” My only objection is that it is not a reversal of ageing but simply a prevention of further deterioration as at 14 months of age, when the intervention starts, mice are still very healthy. “There have been a handful of small clinical trials looking at markers of inflammation and diabetes but they have used a much lower dose than the equivalent of what was used in mice in this study.”ĭoes the press release accurately reflect the science? Have there any research clinical/trials looking into this but in humans? “Definitely not until it is properly tested in a clinical trial.” “This study shows that taurine levels decrease with age in humans.”įollowing these results should we recommend humans take taurine supplements? Is there much research on levels/rates of taurine deficiency in ageing humans? It is important to highlight that this study shows prevention of deterioration rather than reversal of ageing.” This could be a long and expensive study, depending on the time that it takes to see an effect and how effective this drug is in preventing signs of ageing. Secondly, we need to test taurine in a clinical trial to understand if it is effective and the side effects, whether it needs to be taken continuously and from which age. Firstly, we need to see whether it works as well in older organisms (mice or monkeys) when the signs of ageing are more prominent. What can we infer/take from these results done in animal models to humans? It is important to note that the age of the mice is the equivalent of approximately a 50-year-old human, so these are still fairly healthy mice. they have used already collected data and looked at correlation of level of taurine with diabetes. In humans, they have performed a retrospective analysis, i.e. effects on bone and muscle loss, glucose metabolism (important for diabetes), some parameters of depression (anxiety), have been performed in mice. “The most comprehensive experiments testing parameters of health i.e. Were the experiments outlined in the study performed in humans? Prof Ilaria Bellantuono, Professor of Musculoskeletal Ageing, University of Sheffield, said: Expert reaction to study looking at use of supplements to reverse age-related taurine loss and improve longevity in mice and monkeysĪ study published in Science looks at taurine deficiency as a driver of aging. ![]()
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